As part of Neucin Design’s experience in the development of a generic capsule based dry powder inhaler (c-DPI) it was critical to understand and optimise the airflow characteristics of the device to not only match the originator device but also to ensure the inhalation energy provided by the user was harnessed in the most efficient and effective way to achieve optimum drug delivery performance to the lungs.

The airflow energy applied through a device during inhalation and the resulting capsule vibration within a c-DPI chamber is critical, having a significant effect not only drug delivery performance, powder dispersion and fine particle efficiencies but also on the overall device resistance. This is particularly important at low inspiration flow rates where the energy is at its lowest and therefore drug delivery most challenging.

Current equipment for testing c-DPI’s is limited in providing accurate performance data for the critical capsule vibration, dynamic airflow characteristics and resistance. Therefore, Neucin Design has developed a bespoke electromechanical analytical tool that can accurately display, measure and capture capsule vibration and the associated pressure drop across the device which was instrumental in developing the most efficient and effective airflow path throughout the device.